Keratinopathic Ichthyosis
Curth-Macklin Ichthyosis Hystrix (IHCM)
- Beginning: Birth / Childhood.
- Clinical picture: Mild.
- Non-syndromic: Does not affect other organs besides the skin.
Unlike other types of ichthyosis, it does not present blisters, redness, or fragile skin.
The disease appears in early childhood with a thickening of the outer layer of the skin (hyperkeratosis) of a yellow-brown or grayish color, especially in the joints, trunk and extremities.
It causes painful fissures and cracks with bleeding, it might even cause contractures, gangrene or amputation of fingers.
The skin gives off an unpleasant smell and tends to be infected and moderately itchy.
It presents alterations in the nails (nail dystrophy).